ZUMA-12 is the first study evaluating CAR T therapy first-line in high-risk LBCL. The results demonstrated an ORR of 85% and a CR in 74% of patients treated with Axi-Cel. At data cut-off 70% of patients had ongoing responses. Continued follow-up will assess durability of response which, if confirmed, supports the concept that early use of cellular therapies in high risk patients may be a pathway to improved outcomes over chemotherapy.
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